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Epidermolysis Bullosa
Background
Epidermolysis bullosa (EB) is the term used to describe a number of genetically determined disorders whose principal characteristic is skin and/or mucous membrane fragility (for example in the mouth and oesophagus). The skin has a tendency to blister in response to mechanical trauma (such as friction between the skin and clothing). According to the most recent agreement on classification there are four broad categories of EB: EB simplex (EBS), junctional EB (JEB), dystrophic EB (DEB) and mixed (Kindler syndrome). Within each of these categories there is great variability clinically.
