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Epidermolysis Bullosa
Background
Epidermolysis Bullosa (EB) is the term used to describe a number of genetically determined disorders whose principal characteristic is skin and/or mucous membrane fragility (for example in the mouth and oesophagus). The skin has a tendency to blister in response to mechanical trauma (for example any friction between the skin and clothing). Though a large number of distinct types of epidermolysis bullosa have been identified, in practice most cases can be placed in one of three categories: EB simplex, junctional EB and dystrophic EB. These are defined by the level at which there is a split between the epidermis (outer layer) and the dermis (inner layer) of the skin, which results in the characteristic fragility of EB.
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