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Leigh syndrome

Background

Leigh syndrome: Leigh's disease; Leigh's Encephalopathy

This is a disease that affects the brain and gets worse over time. Most patients start having problems by the age of two years, deteriorate rapidly and, sadly, many die within a year or two. Typically, there is a ‘step-wise’ downhill course: patients may deteriorate rapidly and then show partial recovery over a few weeks, followed by periods in which their condition is stable. Other patients have their first problems later in childhood and these patients often survive into adulthood.

What are the symptoms? View What are the symptoms?

Medical text written November 2000 by Dr A Morris. Last updated December 2011 by Dr A Morris, Consultant Paediatrician with Special Interest in Metabolic Disease, Willink Biochemical Genetics Unit, Royal Manchester Children's Hospital, Manchester, UK.

 

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