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Osteopetrosis
Background
Osteopetrosis is general name for a group of rare genetic diseases all of which are characterised by increased bone density. These result from problems in formation or function of osteoclasts, cells which dissolve bone so that it can be reshaped during growth or repaired after injury. The dense bones are prone to fracturing easily. Also, nerves which pass through channels in bone (such as those which pass through the skull to the eye or ear) can be damaged, since these channels do not enlarge as the nerves grow.