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Brittle Bone diseases (Osteogenesis Imperfecta)

How is it treated?

Fractures need to be treated but the immobilisation period should be kept to a minimum as activity allows muscles and bones to stay as strong as possible. It is important for someone with OI to have a well balanced diet with adequate calcium. There is no specific drug therapy for OI but it has been shown that a group of drugs called bisphosphonates can reduce bone loss, the number of fractures and the chronic pain experienced by these children; most children also become more mobile. Most children obtain maximum benefit from this drug over the first two years of treatment. Further research is needed to assess the benefits of treating children with brittle bone disease with this group of drugs. Some children may benefit from insertion of rods to support the bones. Regular monitoring of other functions such as hearing is required.

View Background Background  |  Inheritance patterns and prenatal diagnosis View Inheritance patterns and prenatal diagnosis

Medical text written November 2002 by Dr S F Ahmed. Last updated March 2007 by Dr S F Ahmed, Consultant in Paediatric Endocrinology and Bone Metabolism, Royal Hospital For Sick Children, Yorkhill, Glasgow, UK.

 

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