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Cystic Fibrosis

What are the causes?

Cystic Fibrosis (CF) is caused by a single faulty gene that should normally produce a protein present in the cell wall known as cystic fibrosis transmembrane regulator (CFTR), which controls the passage of salt and water across cell surfaces such as those in the lungs, pancreas gland, bile ducts, intestinal walls and other organs. In CF the secretions are abnormally dry due to their decreased salt and water content and this causes the mucus and secretions to be abnormally sticky. In the lungs infections are difficult to clear and in the digestive system the pancreas is damaged early due to the thick sticky secretions blocking the ducts of the gland.

View What are the symptoms? What are the symptoms?  |  How is it diagnosed? View How is it diagnosed?

Medical text written June 2008 by Dr J Littlewood, Chairman of the Cystic Fibrosis Trust Research and Medical Advisory Committee, Bromley, UK.

 

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