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Fetal Anti-Convulsant syndrome

What are the symptoms?

The risks associated with exposure to more than one anti-convulsant are greater. The type of abnormalities that occur are diverse but include Spina Bifida, Cleft Lip and/or Palate, Upper Limb Abnormalities, Lower Limb Abnormalities, Congenital Heart disease (see Heart defects) and Kidney problems (see Kidney disease). None of these abnormalities are specific for the condition but the facial features of these children may be distinctive, even though quite subtle, especially as toddlers and especially in association with exposure to Epilim (sodium valproate). The facial appearance becomes more normal with age. In addition, a degree of developmental delay and/or behavioural difficulty in affected children is common but there is very little information about what can be expected as the children grow up through adolescence and into adulthood.

View Background Background  |  What are the causes? View What are the causes?

Medical text written June 1998 by Dr P D Turnpenny. Last updated December 2005 by Dr P D Turnpenny, Consultant Clinical Geneticist, Royal Devon & Exeter Hospital, Exeter, UK.

 

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