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Fibrodysplasia Ossificans Progressiva
What are the symptoms?
Most people affected by FOP have some abnormalities of the fingers or toes. The toes are most commonly involved and are often shortened and deviated. These differences are usually apparent at birth.
This bone formation is usually first noticed in early childhood as a series of hard lumps in the neck or along the spine. These lumps, which may be tender, gradually shrink in size as the affected muscles are replaced by bone. The appearance of bony lumps in muscles is usually spontaneous but can also be provoked by any injury to the muscles. Disability in FOP is physical and very variable in extent; intelligence is unaffected.
Injury to the muscles can often provoke local bone formation. For this reason intramuscular injections should be avoided if possible. Similarly operations on the muscles to remove pieces of bone almost invariably result in increased bone formation. Also, some forms of dental treatment may result in bone formation in the jaw muscles and individuals with MOP should inform their dental practitioner.
Background
| What are the causes? 
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