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Haemolytic Uraemic syndrome

What are the causes?

Most children develop HUS after a preceding illness, usually gastroenteritis. The onset of the breakdown of red blood cells and kidney failure is sudden.

It is now believed that the majority of cases of D+HUS are associated with infection by verocytotoxin producing Escherichia coli (VTEC). These organisms are associated with clinical conditions ranging from mild diarrhoea to haemorrhagic colitis and D+HUS. Food borne transmission of VTEC 0157 has been shown to occur in a large number of outbreaks in various parts of the world. Minced beef and dairy produce are the most commonly implicated foods. Infection has also been associated with the consumption of water, vegetables and fruit juice. Person to person spread and contact with livestock have also been documented as modes of transmission of infection in outbreaks in Europe and North America.

View What are the symptoms? What are the symptoms?  |  How is it treated? View How is it treated?

Medical text written June 1998 by Dr M M Fitzpatrick, Consultant Paediatric Nephrologist, St James's University Hospital, Leeds, UK. Last reviewed October 2004 by Dr R Trompeter, Consultant Paediatric Nephrologist, Great Ormond Street Hospital, London, UK.

 

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