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Histiocytosis

What are the symptoms?

Langerhans Cell Histiocytosis (LCH) is very variable, ranging from single skin or bone lesions, which may not require treatment, to a severe illness involving many organs. The pituitary gland is commonly affected and this results in failure to concentrate the urine so that patients drink and excrete large volumes, producing diabetes insipidus (not sugar diabetes, or diabetes mellitus), and they may not grow because of a lack of growth hormone. Other symptoms are very variable because of the large number of organs that may be affected.

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Medical text written December 1997 by Dr David Webb Consultant Paediatric Haematologist/Oncologist, Great Ormond Street Hospital, London, UK. Last updated September 2006 by Professor Peter Beverley, Institute for Vaccine Research, Newbury, UK.

 

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