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McCune-Albright syndrome

Inheritance patterns and prenatal diagnosis

Inheritance patterns
McCune-Albright syndrome is caused by somatic mutations (or changes) in the GNAS1 gene that take place after conception. As these mutations do not take place in the germ cells (egg and sperm), McCune-Albright syndrome is not inherited but sporadic with no other family member, brother or sister likely to be affected.

Prenatal diagnosis
It may sometimes be possible to perform prenatal diagnosis by chorionic villus sampling (CVS) or amniocentesis during pregnancy. Genetic counselling may be helpful for individuals and families affected by this condition.

View What are the symptoms? What are the symptoms?  |  Is there support?  View Is there support? 

Medical text written July 2004 by Contact a Family. Approved July 2004 by Dr R Stanhope, Consultant Paediatric Endocrinologist, Great Ormond Street Hospital, London, UK.

 

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