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Parkinson's disease

What are the causes?

It occurs because Parkinson's affects a part of the brain known as the substantia nigra which plays a vital role in the control of movements. The substantia nigra has nerve cells (neurones) which produce a chemical called dopamine. In Parkinson's, these cells undergo progressive degeneration leading to progressive reduction of available dopamine. Dopamine is a chemical messenger that plays an important role in enabling people to initiate and perform smooth co-ordinated movements.

It is not known why the cells that produce dopamine die. Once eighty per cent of these cells have been destroyed the symptoms of Parkinson's will occur. Symptoms include shaking, muscle stiffness, and slowness of initiating and movement. There is no known cure.

View What are the symptoms? What are the symptoms?  |  How is it treated? View How is it treated?

Medical text written October 2000 by the Parkinson's Disease Society. Approved October 2000 by the Parkinson's Disease Society Medical Advisory Board: Chair, Professor A Williams, Professor of Neurology, Queen Elizabeth Hospital, Birmingham, UK. Last updated June 2005 by the Parkinson's Disease Society. Approved June 2005 by the Parkinson's Disease Society Medical Advisory Board: Chair, Dr. Mahendra Gonsalkorale, Consultant Physician and Clinical Director, Hope Hospital, Salford, UK.

 

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